Some opinions to the draft 4 th list of essential drug in Viet Nam

Section II: changing “anti-temperature” to “anti-pyritic”; 1. analgesic agents with opide containing 2. analgesic agent without opide containing; Section III. The antiallergenic drugs and drugs for hypersensitivity should be changed to the antiallergenic and anti- hypersensitivity agents. Section IV. The anti-toxic: 4.1 specific anti-toxic; 4.2.non- specific anti -toxic agents

Homeopathy therapy

A very low dose of treatment called homeopathy therapy. The scientific basis of applying the homeopathy therapy is symptoms of toxic dose of drug. For example, strychos at toxic dose induces gastro intestinal irritation, nervous system stimulation; Iris versicolor induces joint pain, gastrointestinal irritation and migraine. The homeopathy therapy had been most applied in Europe in 18th century

The tests of acute toxicity

There are some inapropriate problems: 1. The number of mice according to method from 30-100; 2. The weight of mice is 16-22g but most common is 19+/-1g(45 days);3. If oral dosage: 0.2 ml/10 g mice, if body weight:19+/- 1 g: the same dose of 0.4-0.5 ml/mice; 4. As calculating method of Behrens, the number of mice can provide LD 50 with small adds; 5. Safe maximal dose; 6. The mice is monitored mainly during first 24 hours. The monitoring time may be 36-48 hours; 7. The morphological, frequency and amplitude change of all waves in electrocardiogram and encephalogram should be nomitored.

Study on the roborant effect of drug by swimming test in the experimental animal

A study on the roborant effect of drug by swimming test in the experimental rat or mice was carried out. The swimming time calculated from standing swimming until rat was exhausted that can not swim. There were 2 method of calculation, including average swimming time and second swimming time comparing with the first swimming time.

The extrapolation method in dosage is equivalent in effectiveness between man and experimental animals

Introduction on the factors influence dosage that is equivalent in effectiveness between animals. They comprised drug metabolism, minimum concentration have with effect in serum, the effective time, cellular respiration, organic weight rate comparison with body weight, heat production, cytochrom C, volume of kidney and body surface.